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AXSM vs ICLR

AXSM
Axsome Therapeutics, Inc.
BEARISH
Price
$185.96
Market Cap
$9.37B
Sector
Healthcare
AI Confidence
68%
ICLR
ICON Public Limited Company
NEUTRAL
Price
$116.50
Market Cap
$9.06B
Sector
Healthcare
AI Confidence
85%

Valuation

P/E Ratio
AXSM
--
ICLR
15.7
Forward P/E
AXSM
423.03
ICLR
9.49
P/B Ratio
AXSM
126.85
ICLR
0.95
P/S Ratio
AXSM
16.7
ICLR
1.12
EV/EBITDA
AXSM
-49.31
ICLR
7.88

Profitability

Gross Margin
AXSM
91.86%
ICLR
28.16%
Operating Margin
AXSM
-19.25%
ICLR
12.67%
Profit Margin
AXSM
-40.89%
ICLR
7.4%
ROE
AXSM
-275.5%
ICLR
6.27%
ROA
AXSM
-19.79%
ICLR
4.2%

Growth

Revenue Growth
AXSM
63.2%
ICLR
0.6%
Earnings Growth
AXSM
--
ICLR
-98.7%

Financial Health

Debt/Equity
AXSM
2.96
ICLR
0.38
Current Ratio
AXSM
1.57
ICLR
1.06
Quick Ratio
AXSM
1.45
ICLR
1.01

Dividends

Dividend Yield
AXSM
--
ICLR
--
Payout Ratio
AXSM
0.0%
ICLR
0.0%

AI Verdict

AXSM BEARISH

The Advanced Deterministic Scorecard reveals a weak financial health profile with a Piotroski F-Score of just 3/9, indicating significant operational and profitability concerns. Despite strong revenue growth of 63.2% and a bullish analyst recommendation, the company is deeply unprofitable with a -40.89% profit margin, negative ROE of -275.50%, and a high debt/equity ratio of 2.96. Valuation metrics are stretched, with a forward P/E of 423x and a price-to-book of 126.85, while insider selling of $85.54M in the last six months signals strong bearish sentiment from management. Although the stock has delivered impressive price performance over the past year (+79%), these gains appear disconnected from fundamentals, increasing vulnerability to downside correction.

Strengths
Exceptional year-over-year revenue growth of 63.20%, significantly above sector average of 39.78%
High gross margin of 91.86%, indicating strong pricing power and low cost of goods sold
Analyst consensus is strong_buy with a target price of $210.19, implying 13% upside
Risks
Piotroski F-Score of 3/9 indicates weak financial health and poor profitability trends
Extremely high forward P/E of 423x with no Graham Number, suggesting severe overvaluation relative to earnings
Negative ROE of -275.50% and negative operating margins signal deep profitability issues
ICLR NEUTRAL

ICLR presents a stark contrast between strong deterministic health and deteriorating growth fundamentals. While the Piotroski F-Score of 7/9 indicates a strong financial foundation and the stock trades below its Graham Number ($142.86) and Book Value (P/B 0.95), the recent earnings collapse (-98.7% YoY) is a critical concern. The massive PEG ratio of 19.29 suggests the stock is significantly overvalued relative to its current growth trajectory. Despite analyst 'Buy' recommendations, the technical trend remains bearish and revenue growth has stagnated.

Strengths
Strong Piotroski F-Score (7/9) indicating operational health
Low Debt/Equity ratio (0.38) suggesting conservative leverage
Trading below Graham Number ($142.86) and Book Value (P/B 0.95)
Risks
Catastrophic recent earnings growth decline (-98.7% YoY)
Stagnant revenue growth (0.60% YoY) indicating a lack of expansion
Extreme PEG ratio (19.29) signaling poor growth-to-price alignment

Compare Another Pair

AXSM vs ICLR: Head-to-Head Comparison

This page compares Axsome Therapeutics, Inc. (AXSM) and ICON Public Limited Company (ICLR) across key fundamental metrics including valuation ratios, profitability margins, growth rates, financial health indicators, and dividend metrics. Each metric highlights the better-performing stock so you can quickly identify relative strengths and weaknesses.

Our AI engine independently analyzes each company's financials, competitive position, and market conditions to produce a verdict (Bullish, Neutral, or Bearish) along with key strengths and risks. Use this comparison alongside your own research to make informed investment decisions.

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