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EXEL vs IONS

EXEL
Exelixis, Inc.
BULLISH
Price
$44.20
Market Cap
$11.85B
Sector
Healthcare
AI Confidence
70%
IONS
Ionis Pharmaceuticals, Inc.
BEARISH
Price
$75.17
Market Cap
$12.42B
Sector
Healthcare
AI Confidence
85%

Valuation

P/E Ratio
EXEL
15.84
IONS
--
Forward P/E
EXEL
11.25
IONS
-120.83
P/B Ratio
EXEL
5.37
IONS
25.1
P/S Ratio
EXEL
5.11
IONS
13.16
EV/EBITDA
EXEL
11.52
IONS
-33.45

Profitability

Gross Margin
EXEL
96.39%
IONS
1.29%
Operating Margin
EXEL
39.41%
IONS
-105.47%
Profit Margin
EXEL
33.73%
IONS
-40.41%
ROE
EXEL
35.53%
IONS
-70.8%
ROA
EXEL
19.27%
IONS
-7.31%

Growth

Revenue Growth
EXEL
5.6%
IONS
-10.3%
Earnings Growth
EXEL
84.2%
IONS
--

Financial Health

Debt/Equity
EXEL
0.09
IONS
5.35
Current Ratio
EXEL
3.56
IONS
3.83
Quick Ratio
EXEL
3.35
IONS
3.51

Dividends

Dividend Yield
EXEL
--
IONS
--
Payout Ratio
EXEL
0.0%
IONS
0.0%

AI Verdict

EXEL BULLISH

EXEL shows bullish fundamentals based on deterministic rules. Financial strength is stable (F-Score 4/9). Key strengths include strong valuation and growth metrics.

Strengths
Strong profitability (33.7% margin)
Low debt with D/E ratio of 0.09
Strong ROE of 35.5%
Risks
Premium vs Graham Number ($22.74)
IONS BEARISH

IONS presents a significant disconnect between its market valuation and fundamental performance. While the Piotroski F-Score of 5/9 indicates stable financial health, the company is grappling with negative revenue growth (-10.30%) and a severe collapse in YoY EPS (-167.4%). Despite a massive 181% price surge over the last year, the valuation is extreme with a Price/Book of 25.10 and a Price/Sales of 13.16. Heavy insider selling by the CEO and CFO, combined with a bearish technical trend, suggests the current price is driven by speculative pipeline expectations rather than realized value.

Strengths
Strong short-term liquidity with a Current Ratio of 3.83
Consistent history of beating earnings estimates (3 of last 4 quarters)
Strong analyst consensus with a target price of $97.60
Risks
Extreme valuation premiums (P/B 25.10, P/S 13.16)
Negative revenue growth (-10.30% YoY) and declining Q/Q revenue
Severe profitability issues with an operating margin of -105.47%

Compare Another Pair

EXEL vs IONS: Head-to-Head Comparison

This page compares Exelixis, Inc. (EXEL) and Ionis Pharmaceuticals, Inc. (IONS) across key fundamental metrics including valuation ratios, profitability margins, growth rates, financial health indicators, and dividend metrics. Each metric highlights the better-performing stock so you can quickly identify relative strengths and weaknesses.

Our AI engine independently analyzes each company's financials, competitive position, and market conditions to produce a verdict (Bullish, Neutral, or Bearish) along with key strengths and risks. Use this comparison alongside your own research to make informed investment decisions.

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