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MRK vs PTGX

MRK
Merck & Co., Inc.
NEUTRAL
Price
$121.25
Market Cap
$299.79B
Sector
Healthcare
AI Confidence
90%
PTGX
Protagonist Therapeutics, Inc.
NEUTRAL
Price
$105.98
Market Cap
$6.76B
Sector
Healthcare
AI Confidence
80%

Valuation

P/E Ratio
MRK
16.66
PTGX
--
Forward P/E
MRK
12.42
PTGX
-244.06
P/B Ratio
MRK
5.7
PTGX
10.79
P/S Ratio
MRK
4.61
PTGX
146.96
EV/EBITDA
MRK
11.46
PTGX
-39.56

Profitability

Gross Margin
MRK
77.21%
PTGX
100.0%
Operating Margin
MRK
32.77%
PTGX
-677.09%
Profit Margin
MRK
28.08%
PTGX
-282.83%
ROE
MRK
36.88%
PTGX
-20.18%
ROA
MRK
12.04%
PTGX
-13.99%

Growth

Revenue Growth
MRK
5.0%
PTGX
-95.6%
Earnings Growth
MRK
-19.3%
PTGX
--

Financial Health

Debt/Equity
MRK
0.96
PTGX
0.02
Current Ratio
MRK
1.54
PTGX
12.71
Quick Ratio
MRK
0.96
PTGX
12.59

Dividends

Dividend Yield
MRK
2.83%
PTGX
--
Payout Ratio
MRK
45.05%
PTGX
0.0%

AI Verdict

MRK NEUTRAL

MRK shows neutral fundamentals based on deterministic rules. Financial strength is weak (F-Score 3/9). Mixed signals with both opportunities and risks present.

Strengths
Strong profitability (28.1% margin)
Strong ROE of 36.9%
Risks
Premium vs Graham Number ($59.01)
Weak financial trend (Piotroski F-Score: 3/9)
PTGX NEUTRAL

PTGX exhibits a strong deterministic health profile with a Piotroski F-Score of 7/9 and a fortress-like balance sheet (Current Ratio 12.71, Debt/Equity 0.02). However, the company is in a speculative pre-commercial phase, evidenced by a staggering Price/Sales ratio of 146.96 and negative profit margins. While analysts maintain a 'strong_buy' based on the late-stage pipeline (Icotyde and Rusfertide), significant insider selling by the CEO and CFO creates a divergence between institutional optimism and internal sentiment.

Strengths
Strong Piotroski F-Score (7/9) indicating improving financial health
Exceptional liquidity with a Current Ratio of 12.71
Negligible debt levels (Debt/Equity 0.02)
Risks
Binary regulatory risk associated with FDA/EMA approval of Icotyde and Rusfertide
Extreme valuation premiums (P/S 146.96, P/B 10.79)
Severe revenue volatility (-95.6% YoY) typical of milestone-based biotech

Compare Another Pair

MRK vs PTGX: Head-to-Head Comparison

This page compares Merck & Co., Inc. (MRK) and Protagonist Therapeutics, Inc. (PTGX) across key fundamental metrics including valuation ratios, profitability margins, growth rates, financial health indicators, and dividend metrics. Each metric highlights the better-performing stock so you can quickly identify relative strengths and weaknesses.

Our AI engine independently analyzes each company's financials, competitive position, and market conditions to produce a verdict (Bullish, Neutral, or Bearish) along with key strengths and risks. Use this comparison alongside your own research to make informed investment decisions.

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