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LYRA

BEARISH
$0.65 Live
Lyra Therapeutics, Inc. · NASDAQ
$0.31 52W Range $37.5

At a glance

Key valuation, profitability, growth, and risk metrics.

Updated Apr 14, 2026
Market cap
$1.15M
P/E
N/A
ROE
-6595.0%
Profit margin
N/A
Debt/Equity
N/A
Dividend yield
N/A

AI Analysis

AI-powered fundamental assessment

Confidence
95%
LYRA is in a state of severe financial distress, evidenced by a critical Piotroski F-Score of 1/9 and a negative Price-to-Book ratio of -0.25, indicating negative shareholder equity. The company has experienced a catastrophic revenue collapse of -96.70% YoY and an extreme operating margin of -98,728.57%. With a 52-week high of $37.50 now trading at $0.65, the stock has lost nearly all its value. The combination of negative equity, vanishing revenue, and bearish insider activity suggests a high risk of insolvency.

Key Strengths

Current ratio of 1.71 suggests some remaining short-term liquidity
Quick ratio of 1.67 indicates liquidity is not heavily tied to inventory
Recent quarterly EPS losses are smaller in absolute terms than historical peaks
Recent 1-week price bounce (+32.6%) suggests speculative volatility
Positive surprise in the most recent earnings estimate

Key Risks

Extreme bankruptcy risk indicated by negative equity (P/B -0.25)
Catastrophic revenue decline of -96.70% YoY
Severe operational inefficiency with an operating margin of -98,728.57%
Total collapse in share price (-87.8% over 1 year)
Lack of analyst coverage and institutional support

Performance Snowflake

Multi-dimensional analysis across 5 key categories

Overall
3
Weak
Value
0
Future
0
Past
5
Health
10
Dividend
0
AI Verdict
Extreme Risk / Near-Collapse
Key drivers: Negative Equity, Revenue Collapse, Piotroski F-Score 1/9, Insider Selling
Confidence
95%
Value
0/100

P/B of -0.25 indicates the company's liabilities exceed its assets.

Positives
No standout positives identified.
Watchpoints
  • Negative Price/Book ratio
  • No Graham Number available
  • No earnings to support P/E valuation
Future
0/100

Growth metrics are in a state of total collapse.

Positives
No standout positives identified.
Watchpoints
  • Revenue growth of -96.70%
  • Q/Q revenue growth of -96.65%
  • No clear path to profitability
Past
5/100

Historical price performance is a total wipeout.

Positives
  • Some recent EPS beats
Watchpoints
  • 5-year price change of -99.9%
  • Consistent history of massive quarterly losses
Health
10/100

Piotroski score of 1/9 is a definitive signal of financial weakness.

Positives
  • Current ratio > 1.0
Watchpoints
  • Piotroski F-Score 1/9
  • Negative ROE of -6594.98%
  • Negative ROA of -36.06%
Dividend
0/100

Dividend strength is 0/100.

Positives
No standout positives identified.
Watchpoints
  • No dividend history
  • Zero payout capacity

Stock Price & Analyst Targets

Real-time price movements and analyst price targets

Current Price
$0.65

Multi-Horizon Performance vs Peers

Price momentum across 5Y → 1W horizons for LYRA and closest competitors.

Updated 2026-04-13
LYR
Lyra Therapeutics, Inc.
Primary
5Y
-99.9%
3Y
-99.5%
1Y
-87.8%
6M
-91.8%
1M
-50.8%
1W
+32.6%
AKA
Akanda Corp.
Peer
5Y
-100.0%
3Y
-100.0%
1Y
-96.4%
6M
-95.4%
1M
-13.6%
1W
-6.7%
BDR
Biodexa Pharmaceuticals Plc
Peer
5Y
-100.0%
3Y
-100.0%
1Y
-95.1%
6M
-75.6%
1M
-24.0%
1W
-4.0%
ADT
Aditxt, Inc.
Peer
5Y
-100.0%
3Y
-100.0%
1Y
-100.0%
6M
-99.8%
1M
-67.1%
1W
-51.2%
IMC
IM Cannabis Corp.
Peer
5Y
-99.9%
3Y
-91.4%
1Y
-72.7%
6M
-81.3%
1M
-57.0%
1W
+6.5%

Positive values indicate cumulative gains over the specified period. Comparables pulled from the same sector to highlight whether momentum is stock-specific or industry-wide.

Historical Performance Trends

Long-term financial metrics and growth patterns

Revenue & Net Income

Profit & Operating Margins

Return on Equity (ROE)

Quarterly Revenue Growth

Historical data shows last 12 quarters (3 years)

Valuation Metrics

Key valuation ratios and pricing indicators

P/E Ratio
N/A
Forward P/E
-0.66
PEG Ratio
N/A
P/B Ratio
-0.25
P/S Ratio
2.9
EV/Revenue
38.99
EV/EBITDA
-0.53
Market Cap
$1.15M

Profitability

Profit margins and return metrics

Profit Margin N/A
Operating Margin -98728.6%
Gross Margin -152.76%
ROE -6594.98%
ROA -36.06%

Growth

Revenue and earnings growth rates

Revenue Growth -96.7%
Earnings Growth N/A
Q/Q Revenue Growth -96.65%
Q/Q Earnings Growth N/A

Financial Health

Balance sheet strength and liquidity metrics

Debt/Equity
N/A
Current Ratio
1.71
Good
Quick Ratio
1.67
Excellent
Cash/Share
$8.95

Financial Statement Flow

Interactive flow visualization showing how money moves through the company Q4 2025

Revenue
$0.0B
Op. Margin
-98728.6%
Net Margin
-99300.0%
Total Assets
$0.0B
Liabilities
$0.0B
Equity
$-0.0B
Debt/Equity
-4.37x
Operating CF
$-0.0B
CapEx
$-0.0B
Free Cash Flow
$-0.0B
FCF Yield
102%

Quarterly Earnings History

EPS performance vs analyst estimates

2025-11-12
$-3.4
+16.5% surprise
2025-08-12
$-5.22
-9.3% surprise
2025-05-06
$-6.5
+4.9% surprise
2025-03-13
$-7.09
-9.2% surprise

Healthcare Sector Comparison

Comparing LYRA against 319 companies in the Healthcare sector (20 bullish, 107 neutral, 192 bearish)
Return on Equity (ROE)
-6594.98%
This Stock
vs
-86.0%
Sector Avg
+7568.9% (Excellent)
Revenue Growth
-96.7%
This Stock
vs
90.15%
Sector Avg
-207.3% (Slower)
Current Ratio
1.71
This Stock
vs
3.67
Sector Avg
-53.4% (Weaker)

Similar Companies

Peer comparison within the same industry

Recent Insider Trading

Insider buy and sell transactions from the last 6 months

PALASIS MARIA
Chief Executive Officer
Sell
2026-01-06
1,702 shares · $5,726
CAVALIER JASON
Chief Financial Officer
Sell
2026-01-06
769 shares · $2,587
PERCEPTIVE ADVISORS LLC
Beneficial Owner of more than 10% of a Class of Security
Sell
2025-11-13
45,875 shares · $182,515
PERCEPTIVE ADVISORS LLC
Beneficial Owner of more than 10% of a Class of Security
Sell
2025-11-10
70,390 shares · $344,219
Insider transactions can signal confidence or concerns about company prospects

Past News Coverage

Recent headlines mentioning LYRA from our newsroom.

Newest → oldest
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