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SRPT

BEARISH
$21.55 Live
Sarepta Therapeutics, Inc. · NASDAQ
Target $21.78 (+1.1%)
$10.42 52W Range $64.8

At a glance

Key valuation, profitability, growth, and risk metrics.

Updated Apr 20, 2026
Market cap
$2.26B
P/E
N/A
ROE
-53.5%
Profit margin
-32.5%
Debt/Equity
0.91
Dividend yield
N/A

AI Analysis

AI-powered fundamental assessment

Confidence
90%
Sarepta Therapeutics exhibits severe financial distress, highlighted by a critical Piotroski F-Score of 1/9, indicating a near-total failure of fundamental health metrics. The company is grappling with negative gross margins (-7.43%) and a catastrophic collapse in revenue growth (-32.70% YoY), suggesting a failing business model or significant product loss. While the current ratio remains adequate, the combination of negative profitability, bearish insider selling, and a 60% one-year price decline creates a high-risk profile. The stock is currently trading near its analyst target price, leaving little room for upside given the deteriorating fundamentals.

Key Strengths

Current Ratio of 2.32 indicates short-term liquidity is still intact
Quick Ratio of 1.33 suggests ability to cover immediate liabilities
Low Price-to-Sales ratio (1.03) relative to typical biotech premiums
Forward P/E of 7.17 suggests potential for recovery if earnings stabilize
Price/Book ratio (1.98) is not excessively inflated

Key Risks

Critical Piotroski F-Score (1/9) signaling extreme financial weakness
Negative Gross Margin (-7.43%) indicates the cost of goods exceeds revenue
Severe revenue contraction (-32.70% YoY) and EPS collapse (-306.8%)
Bearish insider sentiment with recent sales by the COO and a Director
Long-term price destruction with a 3-year decline of 82.8%
AI Fair Value Estimate
Based on comprehensive analysis
$18.5
-14.2% below current price

Performance Snowflake

Multi-dimensional analysis across 5 key categories

Overall
15
Weak
Value
40
Future
10
Past
15
Health
12
Dividend
0
AI Verdict
High Risk / Speculative
Key drivers: Piotroski F-Score 1/9, Negative Revenue Growth, Negative Gross Margins, Bearish Technical Trend
Confidence
95%
Value
40/100

Ref P/E 7.17, P/S 1.03

Positives
  • Low P/S ratio
  • Low Forward P/E
Watchpoints
  • Negative earnings make P/E irrelevant
  • Graham Number unavailable due to lack of positive earnings
Future
10/100

Ref Growth rates

Positives
No standout positives identified.
Watchpoints
  • Revenue growth -32.70%
  • EPS growth -306.8%
  • Negative operating margins
Past
15/100

Ref Historical trends

Positives
  • Recent 1-month bounce (+25.6%)
Watchpoints
  • 1Y Change -59.9%
  • 3Y Change -82.8%
  • 5Y Change -69.3%
Health
12/100

Ref Piotroski F-Score

Positives
  • Current Ratio 2.32
Watchpoints
  • Piotroski F-Score 1/9
  • ROE -53.47%
  • Operating Margin -92.58%
Dividend
0/100

Ref Yield, Payout

Positives
No standout positives identified.
Watchpoints
  • No dividend paid
  • 0/100 Dividend Strength

Stock Price & Analyst Targets

Real-time price movements and analyst price targets

Current Price
$21.55
Analyst Target
$21.78
Upside/Downside
+1.1%

Multi-Horizon Performance vs Peers

Price momentum across 5Y → 1W horizons for SRPT and closest competitors.

Updated 2026-04-17
SRP
Sarepta Therapeutics, Inc.
Primary
5Y
-69.3%
3Y
-82.8%
1Y
-59.9%
6M
-4.3%
1M
+25.6%
1W
+1.8%
DAW
Day One Biopharmaceuticals, Inc.
Peer
5Y
-8.7%
3Y
+69.0%
1Y
+205.7%
6M
+189.6%
1M
+0.6%
1W
+0.1%
HTF
Heartflow, Inc.
Peer
5Y
-10.1%
3Y
-10.1%
1Y
-10.1%
6M
-19.5%
1M
+21.3%
1W
+8.5%
ATE
Alphatec Holdings, Inc.
Peer
5Y
+4.7%
3Y
+20.4%
1Y
+33.9%
6M
+44.4%
1M
-24.8%
1W
-11.9%
STO
Stoke Therapeutics, Inc.
Peer
5Y
+22.0%
3Y
+332.9%
1Y
+384.7%
6M
+11.2%
1M
+20.1%
1W
+8.6%

Positive values indicate cumulative gains over the specified period. Comparables pulled from the same sector to highlight whether momentum is stock-specific or industry-wide.

Historical Performance Trends

Long-term financial metrics and growth patterns

Revenue & Net Income

Profit & Operating Margins

Return on Equity (ROE)

Quarterly Revenue Growth

Historical data shows last 12 quarters (3 years)

Valuation Metrics

Key valuation ratios and pricing indicators

P/E Ratio
N/A
Forward P/E
7.17
PEG Ratio
-0.09
P/B Ratio
1.98
P/S Ratio
1.03
EV/Revenue
1.07
EV/EBITDA
-3.85
Market Cap
$2.26B

Profitability

Profit margins and return metrics

Profit Margin -32.45%
Operating Margin -92.58%
Gross Margin -7.43%
ROE -53.47%
ROA -11.24%

Growth

Revenue and earnings growth rates

Revenue Growth -32.7%
Earnings Growth N/A
Q/Q Revenue Growth -32.73%
Q/Q Earnings Growth N/A

Financial Health

Balance sheet strength and liquidity metrics

Debt/Equity
0.91
Moderate
Current Ratio
2.32
Strong
Quick Ratio
1.33
Good
Cash/Share
$8.95

Financial Statement Flow

Interactive flow visualization showing how money moves through the company Q4 2025

Revenue
$0.4B
Gross Margin
10.0%
Op. Margin
-92.6%
Net Margin
-63.9%
Total Assets
$3.3B
Liabilities
$2.2B
Equity
$1.1B
Debt/Equity
1.94x
Operating CF
$0.1B
CapEx
$-0.0B
Free Cash Flow
$0.1B
FCF Yield
97%

Quarterly Earnings History

EPS performance vs analyst estimates

2026-05-06
$N/A
2026-02-25
$-3.93
-215.6% surprise
2025-11-03
$-0.13
+65.0% surprise
2025-08-06
$2.02
+73.9% surprise

Healthcare Sector Comparison

Comparing SRPT against 470 companies in the Healthcare sector (26 bullish, 143 neutral, 301 bearish)
Return on Equity (ROE)
-53.47%
This Stock
vs
-97.91%
Sector Avg
-45.4% (Below Avg)
Profit Margin
-32.45%
This Stock
vs
-16.16%
Sector Avg
+100.8% (Superior)
Debt to Equity
0.91
This Stock
vs
3.0
Sector Avg
-69.6% (Less Debt)
Revenue Growth
-32.7%
This Stock
vs
142.9%
Sector Avg
-122.9% (Slower)
Current Ratio
2.32
This Stock
vs
4.65
Sector Avg
-50.2% (Weaker)

Similar Companies

Peer comparison within the same industry

Recent Insider Trading

Insider buy and sell transactions from the last 6 months

MAYO STEPHEN L.
Director
Sell
2026-03-12
7,239 shares · $123,208
RODINO-KLAPAC LOUISE
Officer
Stock Award
2026-02-27
8,125 shares
ESTEPAN IAN MICHAEL
Chief Operating Officer
Stock Award
2026-02-27
8,125 shares
ESTEPAN IAN MICHAEL
Chief Operating Officer
Option Exercise
2026-02-26
7,450 shares · $102,140
NICAISE CLAUDE M.D.
Director
Option Exercise
2026-01-29
10,500 shares · $143,955
BEHRENS M KATHLEEN
Director
Option Exercise
2026-01-27
10,500 shares · $143,955
ESTEPAN IAN MICHAEL
Chief Operating Officer
Sell
2025-12-16
13,187 shares · $294,202
INGRAM DOUGLAS S
Chief Executive Officer
Stock Award
2025-12-05
539,084 shares
Insider transactions can signal confidence or concerns about company prospects

SEC Filings

Recent regulatory filings from the SEC EDGAR database

10-K
10-K
2026-03-02

SRPT filed its annual 10-K report on March 2, 2026, which includes detailed sections on business operations, risk factors, and management's discussion and analysis. Specific financial highlights and risk details were not provided in the available excerpts.

8-K
8-K
2026-02-25

Sarepta Therapeutics likely reported its fourth-quarter and full-year financial results.

8-K
8-K
2026-02-25

Sarepta Therapeutics likely reported its fourth-quarter and full-year financial results.

8-K
8-K
2026-01-12
8-K
8-K
2025-12-19
8-K
8-K
2025-12-11
8-K
8-K
2025-12-08
10-Q
10-Q
2025-11-06

Sarepta Therapeutics is leveraging manufacturing partnerships to support its PMO and gene therapy pipelines, including the SRP-9003 LGMD program. The company faces significant regulatory risks, including an FDA clinical hold on LGMD trials, the revocation of its AAVrh74 platform designation, and potential adverse outcomes from the ESSENCE confirmatory trial for VYONDYS and AMONDYS. Additional headwinds include the impacts of the ELEVIDYS suspension and broader government healthcare cost-containment and pricing reforms.

8-K
8-K
2025-11-03

Sarepta Therapeutics filed an 8-K, likely reporting its third-quarter financial results for 2025.

8-K
8-K
2025-08-29
8-K
8-K
2025-08-21
8-K
8-K
2025-08-13
10-Q
10-Q
2025-08-06
8-K
8-K
2025-07-21
8-K
8-K
2025-07-16
Data sourced from SEC EDGAR. AI summaries generated automatically.

Wall Street Analysts

Professional analyst ratings and price targets

Consensus
HOLD
23 analysts
HC Wainwright & Co.
2026-04-16
reit
Sell Sell
Citigroup
2026-03-26
Maintains
Sell Sell
Needham
2026-03-26
reit
Underperform Underperform
Oppenheimer
2026-03-19
reit
Outperform Outperform
Mizuho
2026-03-13
Maintains
Outperform Outperform
Citigroup
2026-03-10
Maintains
Sell Sell
HC Wainwright & Co.
2026-03-02
reit
Sell Sell
Wells Fargo
2026-02-27
Maintains
Overweight Overweight
HC Wainwright & Co.
2026-01-27
reit
Sell Sell
Wedbush
2026-01-23
Maintains
Outperform Outperform

Past News Coverage

Recent headlines mentioning SRPT from our newsroom.

Newest → oldest
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