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Markets Score 30 Neutral

Nasdaq 100 Sees Mixed Early Trading Across Tech and Biotech

Apr 21, 2026 14:22 UTC
ZS, ALNY, AMGN, MRVL
Immediate term

Zscaler and Marvell Technology led gains in early Tuesday trading, while Alnylam Pharmaceuticals and Amgen faced downward pressure. The movements highlight continued volatility for several high-growth index constituents.

  • Zscaler (ZS) rose 3.0% in early trading
  • Marvell Technology (MRVL) increased by 2.8%
  • Alnylam Pharmaceuticals (ALNY) fell 2.9%
  • Amgen traded down 2.1%
  • Zscaler is down 38.3% year-to-date
  • Alnylam is down 24.0% year-to-date

Early trading on Tuesday showed fragmented performance across the Nasdaq 100, with notable swings in the cybersecurity and biotechnology sectors. The price action reflects ongoing volatility for several growth-oriented stocks, some of which are attempting to recover from steep losses earlier in the year. Zscaler (ZS) emerged as one of the day's top performers, climbing 3.0% in the early session. Despite this short-term bounce, the company continues to struggle with a challenging year, having lost approximately 38.3% of its value year-to-date. In the semiconductor space, Marvell Technology (MRVL) also showed strength, trading up 2.8%. Conversely, the biotechnology sector saw declines. Alnylam Pharmaceuticals (ALNY) was among the worst-performing components of the index, dropping 2.9% on Tuesday. This decline adds to a broader downward trend for the company, which is down roughly 24.0% since the start of the year. Amgen also traded lower, falling 2.1%. These movements represent routine intraday volatility within the tech-heavy index. Without specific fundamental catalysts or news events reported, the shifts likely reflect technical trading patterns or broader sector rotations among institutional investors.

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