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ALEC vs AZN

ALEC
Alector, Inc.
BEARISH
Price
$2.20
Market Cap
$242.8M
Sector
Healthcare
AI Confidence
85%
AZN
AstraZeneca PLC
NEUTRAL
Price
$92.95
Market Cap
$288.2B
Sector
Healthcare
AI Confidence
75%

Valuation

P/E Ratio
ALEC
--
AZN
30.48
Forward P/E
ALEC
-2.22
AZN
18.17
P/B Ratio
ALEC
7.91
AZN
3.14
P/S Ratio
ALEC
11.54
AZN
4.96
EV/EBITDA
ALEC
-0.16
AZN
8.26

Profitability

Gross Margin
ALEC
0.0%
AZN
83.26%
Operating Margin
ALEC
-587.53%
AZN
24.11%
Profit Margin
ALEC
0.0%
AZN
16.17%
ROE
ALEC
-181.56%
AZN
21.67%
ROA
ALEC
-25.13%
AZN
9.06%

Growth

Revenue Growth
ALEC
-88.5%
AZN
12.0%
Earnings Growth
ALEC
--
AZN
78.0%

Financial Health

Debt/Equity
ALEC
1.18
AZN
0.71
Current Ratio
ALEC
3.83
AZN
0.88
Quick Ratio
ALEC
3.68
AZN
0.69

Dividends

Dividend Yield
ALEC
--
AZN
1.71%
Payout Ratio
ALEC
0.0%
AZN
51.99%

AI Verdict

ALEC BEARISH

ALEC's Advanced Deterministic Scorecard reveals significant financial distress: a Piotroski F-Score of 4/9 indicates weak operational health, and the absence of an Altman Z-Score (with a Debt/Equity of 1.18 and negative ROE/ROA) raises bankruptcy risk concerns. Despite a recent 1Y return of +53.9%, the stock trades at extreme valuation multiples (Price/Sales 11.54, Price/Book 7.91) with no profitability, negative earnings, and a staggering -88.5% YoY revenue decline. Insider selling of $0.49M over six months, including large sales by top executives, signals poor confidence. The analyst consensus of 'hold' reflects cautious optimism, but the fundamental deterioration and lack of sustainable value drivers suggest limited upside.

Strengths
Recent quarterly earnings have consistently beaten estimates (3/4 in last 4 quarters)
Average earnings surprise of 19.79% in the last four quarters indicates strong execution on guidance
High current and quick ratios (3.83 and 3.68) suggest strong short-term liquidity
Risks
Piotroski F-Score of 4/9 indicates weak financial health and operational stability
Negative ROE (-181.56%) and ROA (-25.13%) reflect severe capital inefficiency
Revenue has collapsed by 88.5% YoY, signaling fundamental business deterioration
AZN NEUTRAL

AstraZeneca's deterministic health score is concerning with a Piotroski F-Score of 4/9, indicating marginal financial stability. While profitability metrics like ROE (21.67%) and gross margin (83.26%) are strong, the current price of $92.95 trades significantly above the Graham Number of $45.06, reflecting high growth expectations. Revenue and earnings growth are robust (12% and 78% YoY, respectively), but recent earnings surprises have been volatile, including a -25.9% miss in Q3 2025. Analysts maintain a strong_buy recommendation, though insider selling and weak technical trends (10/100) suggest caution near-term.

Strengths
Exceptional gross margin of 83.26% indicates strong pricing power and cost control
High ROE of 21.67% reflects efficient use of shareholder equity
Strong earnings growth of 78% YoY and solid revenue growth of 12% demonstrate momentum
Risks
Piotroski F-Score of 4/9 indicates weak financial health, particularly in liquidity and earnings consistency
Current Ratio of 0.88 and Quick Ratio of 0.69 signal potential short-term liquidity pressure
Earnings volatility with multiple recent misses, including a -25.9% surprise in Q3 2025

Compare Another Pair

ALEC vs AZN: Head-to-Head Comparison

This page compares Alector, Inc. (ALEC) and AstraZeneca PLC (AZN) across key fundamental metrics including valuation ratios, profitability margins, growth rates, financial health indicators, and dividend metrics. Each metric highlights the better-performing stock so you can quickly identify relative strengths and weaknesses.

Our AI engine independently analyzes each company's financials, competitive position, and market conditions to produce a verdict (Bullish, Neutral, or Bearish) along with key strengths and risks. Use this comparison alongside your own research to make informed investment decisions.

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