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AZN vs LYEL

AZN
AstraZeneca PLC
NEUTRAL
Price
$92.95
Market Cap
$288.2B
Sector
Healthcare
AI Confidence
75%
LYEL
Lyell Immunopharma, Inc.
BEARISH
Price
$24.80
Market Cap
$578.5M
Sector
Healthcare
AI Confidence
85%

Valuation

P/E Ratio
AZN
30.48
LYEL
--
Forward P/E
AZN
18.17
LYEL
-29.52
P/B Ratio
AZN
3.14
LYEL
2.12
P/S Ratio
AZN
4.96
LYEL
16070.7
EV/EBITDA
AZN
8.26
LYEL
-2.06

Profitability

Gross Margin
AZN
83.26%
LYEL
100.0%
Operating Margin
AZN
24.11%
LYEL
-1024630.0%
Profit Margin
AZN
16.17%
LYEL
0.0%
ROE
AZN
21.67%
LYEL
-86.98%
ROA
AZN
9.06%
LYEL
-29.83%

Growth

Revenue Growth
AZN
12.0%
LYEL
-45.5%
Earnings Growth
AZN
78.0%
LYEL
--

Financial Health

Debt/Equity
AZN
0.71
LYEL
0.21
Current Ratio
AZN
0.88
LYEL
5.28
Quick Ratio
AZN
0.69
LYEL
5.0

Dividends

Dividend Yield
AZN
1.71%
LYEL
--
Payout Ratio
AZN
51.99%
LYEL
0.0%

AI Verdict

AZN NEUTRAL

AstraZeneca's deterministic health score is concerning with a Piotroski F-Score of 4/9, indicating marginal financial stability. While profitability metrics like ROE (21.67%) and gross margin (83.26%) are strong, the current price of $92.95 trades significantly above the Graham Number of $45.06, reflecting high growth expectations. Revenue and earnings growth are robust (12% and 78% YoY, respectively), but recent earnings surprises have been volatile, including a -25.9% miss in Q3 2025. Analysts maintain a strong_buy recommendation, though insider selling and weak technical trends (10/100) suggest caution near-term.

Strengths
Exceptional gross margin of 83.26% indicates strong pricing power and cost control
High ROE of 21.67% reflects efficient use of shareholder equity
Strong earnings growth of 78% YoY and solid revenue growth of 12% demonstrate momentum
Risks
Piotroski F-Score of 4/9 indicates weak financial health, particularly in liquidity and earnings consistency
Current Ratio of 0.88 and Quick Ratio of 0.69 signal potential short-term liquidity pressure
Earnings volatility with multiple recent misses, including a -25.9% surprise in Q3 2025
LYEL BEARISH

LYEL exhibits critical financial weakness, highlighted by a Piotroski F-Score of 1/9, indicating severe deterioration in fundamental health. Despite a speculative 1-year price rally of 178.7%, the company suffers from extreme operating losses (-1,024,633% margin) and negative revenue growth (-45.50%). The valuation is disconnected from fundamentals, evidenced by an astronomical Price/Sales ratio, while insider sentiment remains bearish with consistent selling by top executives.

Strengths
Strong short-term liquidity with a Current Ratio of 5.28
Low leverage with a Debt/Equity ratio of 0.21
Positive analyst sentiment with a mean target price of $34.80
Risks
Critical financial health as indicated by a 1/9 Piotroski F-Score
Extreme cash burn and negative operating margins
Negative revenue growth (-45.50% YoY) and EPS contraction

Compare Another Pair

AZN vs LYEL: Head-to-Head Comparison

This page compares AstraZeneca PLC (AZN) and Lyell Immunopharma, Inc. (LYEL) across key fundamental metrics including valuation ratios, profitability margins, growth rates, financial health indicators, and dividend metrics. Each metric highlights the better-performing stock so you can quickly identify relative strengths and weaknesses.

Our AI engine independently analyzes each company's financials, competitive position, and market conditions to produce a verdict (Bullish, Neutral, or Bearish) along with key strengths and risks. Use this comparison alongside your own research to make informed investment decisions.

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