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KPTI vs MRK

KPTI
Karyopharm Therapeutics Inc.
BEARISH
Price
$8.00
Market Cap
$180.3M
Sector
Healthcare
AI Confidence
90%
MRK
Merck & Co., Inc.
NEUTRAL
Price
$121.25
Market Cap
$299.79B
Sector
Healthcare
AI Confidence
90%

Valuation

P/E Ratio
KPTI
--
MRK
16.66
Forward P/E
KPTI
-1.83
MRK
12.42
P/B Ratio
KPTI
-0.5
MRK
5.7
P/S Ratio
KPTI
1.23
MRK
4.61
EV/EBITDA
KPTI
-4.3
MRK
11.46

Profitability

Gross Margin
KPTI
9.93%
MRK
77.21%
Operating Margin
KPTI
-52.36%
MRK
32.77%
Profit Margin
KPTI
-134.21%
MRK
28.08%
ROE
KPTI
--
MRK
36.88%
ROA
KPTI
-41.56%
MRK
12.04%

Growth

Revenue Growth
KPTI
11.6%
MRK
5.0%
Earnings Growth
KPTI
--
MRK
-19.3%

Financial Health

Debt/Equity
KPTI
--
MRK
0.96
Current Ratio
KPTI
1.12
MRK
1.54
Quick Ratio
KPTI
0.98
MRK
0.96

Dividends

Dividend Yield
KPTI
--
MRK
2.83%
Payout Ratio
KPTI
0.0%
MRK
45.05%

AI Verdict

KPTI BEARISH

KPTI exhibits severe financial distress, highlighted by a critical Piotroski F-Score of 1/9 and a negative Price-to-Book ratio of -0.50, indicating negative shareholder equity. While the stock has seen a speculative 1-year price surge of 100.5%, the underlying fundamentals are catastrophic with a profit margin of -134.21% and a consistent track record of missing earnings estimates (0/4 in the last year). Despite bullish analyst targets, the combination of insider selling and extreme operational inefficiency suggests a high risk of further capital erosion.

Strengths
Positive year-over-year revenue growth of 11.60%
Recent 1-year price recovery (+100.5%)
Improving EPS growth trend (+38.1% YoY), though still deeply negative
Risks
Negative Book Value (P/B -0.50) indicating insolvency risk
Extreme operational losses (Profit Margin -134.21%)
Critical Piotroski F-Score (1/9) signaling fundamental weakness
MRK NEUTRAL

MRK shows neutral fundamentals based on deterministic rules. Financial strength is weak (F-Score 3/9). Mixed signals with both opportunities and risks present.

Strengths
Strong profitability (28.1% margin)
Strong ROE of 36.9%
Risks
Premium vs Graham Number ($59.01)
Weak financial trend (Piotroski F-Score: 3/9)

Compare Another Pair

KPTI vs MRK: Head-to-Head Comparison

This page compares Karyopharm Therapeutics Inc. (KPTI) and Merck & Co., Inc. (MRK) across key fundamental metrics including valuation ratios, profitability margins, growth rates, financial health indicators, and dividend metrics. Each metric highlights the better-performing stock so you can quickly identify relative strengths and weaknesses.

Our AI engine independently analyzes each company's financials, competitive position, and market conditions to produce a verdict (Bullish, Neutral, or Bearish) along with key strengths and risks. Use this comparison alongside your own research to make informed investment decisions.

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