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PTGX vs RGEN

PTGX
Protagonist Therapeutics, Inc.
NEUTRAL
Price
$105.98
Market Cap
$6.76B
Sector
Healthcare
AI Confidence
80%
RGEN
Repligen Corporation
NEUTRAL
Price
$117.82
Market Cap
$6.64B
Sector
Healthcare
AI Confidence
90%

Valuation

P/E Ratio
PTGX
--
RGEN
137.0
Forward P/E
PTGX
-244.06
RGEN
47.01
P/B Ratio
PTGX
10.79
RGEN
3.15
P/S Ratio
PTGX
146.96
RGEN
8.99
EV/EBITDA
PTGX
-39.56
RGEN
52.71

Profitability

Gross Margin
PTGX
100.0%
RGEN
52.65%
Operating Margin
PTGX
-677.09%
RGEN
8.26%
Profit Margin
PTGX
-282.83%
RGEN
6.62%
ROE
PTGX
-20.18%
RGEN
2.4%
ROA
PTGX
-13.99%
RGEN
0.99%

Growth

Revenue Growth
PTGX
-95.6%
RGEN
18.1%
Earnings Growth
PTGX
--
RGEN
--

Financial Health

Debt/Equity
PTGX
0.02
RGEN
0.33
Current Ratio
PTGX
12.71
RGEN
8.37
Quick Ratio
PTGX
12.59
RGEN
6.82

Dividends

Dividend Yield
PTGX
--
RGEN
--
Payout Ratio
PTGX
0.0%
RGEN
0.0%

AI Verdict

PTGX NEUTRAL

PTGX exhibits a strong deterministic health profile with a Piotroski F-Score of 7/9 and a fortress-like balance sheet (Current Ratio 12.71, Debt/Equity 0.02). However, the company is in a speculative pre-commercial phase, evidenced by a staggering Price/Sales ratio of 146.96 and negative profit margins. While analysts maintain a 'strong_buy' based on the late-stage pipeline (Icotyde and Rusfertide), significant insider selling by the CEO and CFO creates a divergence between institutional optimism and internal sentiment.

Strengths
Strong Piotroski F-Score (7/9) indicating improving financial health
Exceptional liquidity with a Current Ratio of 12.71
Negligible debt levels (Debt/Equity 0.02)
Risks
Binary regulatory risk associated with FDA/EMA approval of Icotyde and Rusfertide
Extreme valuation premiums (P/S 146.96, P/B 10.79)
Severe revenue volatility (-95.6% YoY) typical of milestone-based biotech
RGEN NEUTRAL

RGEN shows neutral fundamentals based on deterministic rules. Financial strength is stable (F-Score 4/9). Mixed signals with both opportunities and risks present.

Strengths
Strong revenue growth of 18.1%
Low debt with D/E ratio of 0.33
Risks
High valuation with P/E of 137.0
Premium vs Graham Number ($26.9)
Weak ROE of 2.4%

Compare Another Pair

PTGX vs RGEN: Head-to-Head Comparison

This page compares Protagonist Therapeutics, Inc. (PTGX) and Repligen Corporation (RGEN) across key fundamental metrics including valuation ratios, profitability margins, growth rates, financial health indicators, and dividend metrics. Each metric highlights the better-performing stock so you can quickly identify relative strengths and weaknesses.

Our AI engine independently analyzes each company's financials, competitive position, and market conditions to produce a verdict (Bullish, Neutral, or Bearish) along with key strengths and risks. Use this comparison alongside your own research to make informed investment decisions.

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