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SEPN

NEUTRAL
$26.13 Live
Septerna, Inc. · NASDAQ
Target $44.43 (+70.0%)
$5.73 52W Range $32.63

At a glance

Key valuation, profitability, growth, and risk metrics.

Updated Apr 19, 2026
Market cap
$1.17B
P/E
N/A
ROE
-12.2%
Profit margin
-106.4%
Debt/Equity
0.06
Dividend yield
N/A

AI Analysis

AI-powered fundamental assessment

Confidence
85%
Septerna exhibits a stark disconnect between fundamental financial health and market sentiment. The Piotroski F-Score of 2/9 indicates weak financial health, characterized by negative profitability and consistent earnings misses (0/4 beats in the last year). However, the company maintains a strong liquidity position with a Current Ratio of 4.73 and very low debt (D/E 0.06), which is typical for a clinical-stage biotech. While analysts maintain a 'strong_buy' rating with a target of $44.43, the combination of bearish insider selling and a high Price/Sales ratio (25.54) suggests a highly speculative valuation based on future pipeline success rather than current performance.

Key Strengths

Strong liquidity with a Current Ratio of 4.73
Very low leverage (Debt/Equity of 0.06)
Explosive year-over-year revenue growth (11,276%)
Strong analyst consensus (Strong Buy) with significant upside potential to target
Impressive 1-year price appreciation (+342.9%)

Key Risks

Weak deterministic health (Piotroski F-Score 2/9)
Severe negative profit margins (-106.37%)
Consistent failure to meet earnings estimates (Average surprise -93.75%)
Bearish insider activity with $2.16M in recent sales
Extremely high valuation relative to sales (P/S 25.54)

Performance Snowflake

Multi-dimensional analysis across 5 key categories

Overall
35
Weak
Value
20
Future
75
Past
50
Health
30
Dividend
0
AI Verdict
Speculative Growth
Key drivers: Clinical pipeline expectations, Strong balance sheet liquidity, Poor operational profitability
Confidence
90%
Value
20/100

Graham Number and Intrinsic Value are unavailable due to lack of positive earnings.

Positives
  • Low Debt/Equity
Watchpoints
  • P/S ratio of 25.54 is excessive
  • Negative P/E and Forward P/E
Future
75/100

Growth is driven by early-stage biotech milestones rather than sustainable cash flow.

Positives
  • Massive revenue growth
  • High analyst price targets ($44.43)
Watchpoints
  • Consistent earnings misses
Past
50/100

Price performance has decoupled from fundamental earnings results.

Positives
  • Exceptional 1-year price return
Watchpoints
  • Poor earnings track record
  • Negative EPS progression
Health
30/100

Altman Z-Score not provided, but F-Score indicates significant fundamental weakness.

Positives
  • High Current and Quick ratios
Watchpoints
  • Piotroski F-Score of 2/9
  • Negative ROE and ROA
Dividend
0/100

Typical for growth-stage biotechnology companies.

Positives
No standout positives identified.
Watchpoints
  • No dividend paid

Stock Price & Analyst Targets

Real-time price movements and analyst price targets

Current Price
$26.13
Analyst Target
$44.43
Upside/Downside
+70.0%

Multi-Horizon Performance vs Peers

Price momentum across 5Y → 1W horizons for SEPN and closest competitors.

Updated 2026-04-17
SEP
Septerna, Inc.
Primary
5Y
+22.1%
3Y
+22.1%
1Y
+342.9%
6M
+18.4%
1M
+8.4%
1W
+13.2%
EYP
EyePoint, Inc.
Peer
5Y
+41.6%
3Y
+326.8%
1Y
+243.1%
6M
+2.1%
1M
-9.6%
1W
+8.8%
ALV
Alvotech
Peer
5Y
-65.9%
3Y
-71.8%
1Y
-66.2%
6M
-52.0%
1M
-17.7%
1W
-1.6%
IRM
IRADIMED CORPORATION
Peer
5Y
+324.4%
3Y
+136.8%
1Y
+89.2%
6M
+31.5%
1M
-7.3%
1W
-2.9%
BLF
BioLife Solutions, Inc.
Peer
5Y
-40.8%
3Y
-0.5%
1Y
-10.7%
6M
+10.1%
1M
-2.1%
1W
+1.8%

Positive values indicate cumulative gains over the specified period. Comparables pulled from the same sector to highlight whether momentum is stock-specific or industry-wide.

Historical Performance Trends

Long-term financial metrics and growth patterns

Revenue & Net Income

Profit & Operating Margins

Return on Equity (ROE)

Quarterly Revenue Growth

Historical data shows last 12 quarters (3 years)

Valuation Metrics

Key valuation ratios and pricing indicators

P/E Ratio
N/A
Forward P/E
-13.43
PEG Ratio
N/A
P/B Ratio
3.07
P/S Ratio
25.54
EV/Revenue
17.54
EV/EBITDA
-10.18
Market Cap
$1.17B

Profitability

Profit margins and return metrics

Profit Margin -106.37%
Operating Margin -66.44%
Gross Margin 100.0%
ROE -12.19%
ROA -9.59%

Growth

Revenue and earnings growth rates

Revenue Growth +11276.4%
Earnings Growth N/A
Q/Q Revenue Growth +11276.4%
Q/Q Earnings Growth N/A

Financial Health

Balance sheet strength and liquidity metrics

Debt/Equity
0.06
Low debt
Current Ratio
4.73
Strong
Quick Ratio
4.66
Excellent
Cash/Share
$8.71

Financial Statement Flow

Interactive flow visualization showing how money moves through the company Q4 2025

Revenue
$0.0B
Op. Margin
-66.4%
Net Margin
-44.5%
Total Assets
$0.6B
Liabilities
$0.2B
Equity
$0.4B
Debt/Equity
0.56x
Operating CF
$-0.0B
CapEx
$-0.0B
Free Cash Flow
$-0.0B
FCF Yield
100%

Quarterly Earnings History

EPS performance vs analyst estimates

2026-05-07
$N/A
2026-03-09
$-0.24
-8.5% surprise
2025-11-10
$-0.1
-112.3% surprise
2025-08-11
$-0.56
-160.4% surprise

Healthcare Sector Comparison

Comparing SEPN against 447 companies in the Healthcare sector (26 bullish, 140 neutral, 281 bearish)
Return on Equity (ROE)
-12.19%
This Stock
vs
-97.42%
Sector Avg
-87.5% (Below Avg)
Profit Margin
-106.37%
This Stock
vs
-14.95%
Sector Avg
+611.5% (Superior)
Debt to Equity
0.06
This Stock
vs
3.06
Sector Avg
-98.0% (Less Debt)
Revenue Growth
11276.4%
This Stock
vs
147.85%
Sector Avg
+7526.8% (Fast Growth)
Current Ratio
4.73
This Stock
vs
4.68
Sector Avg
+1.1% (Better)

Similar Companies

Peer comparison within the same industry

Recent Insider Trading

Insider buy and sell transactions from the last 6 months

SHAIKHLY SAMIRA
Officer
Sell
2026-03-02
70,453 shares · $1,979,838
SHAIKHLY SAMIRA
Officer
Option Exercise
2026-03-02
70,453 shares · $129,456
BHATT ELIZABETH
President
Sell
2026-02-18
4,000 shares · $115,860
BHATT ELIZABETH
President
Option Exercise
2026-02-18
4,000 shares · $27,240
LONG DANIEL D
Officer
Sell
2025-11-10
3,501 shares · $63,223
Insider transactions can signal confidence or concerns about company prospects

SEC Filings

Recent regulatory filings from the SEC EDGAR database

8-K
8-K
2026-04-13

Septerna filed an 8-K on April 13, 2026, likely to report its first-quarter financial results or provide an update on its clinical pipeline.

10-K
10-K
2026-03-09

SEPN filed its annual 10-K report on March 9, 2026. Due to the absence of detailed excerpts, specific financial highlights and risk factors are not available for summary.

8-K
8-K
2026-03-09
8-K
8-K
2026-03-02
8-K
8-K
2026-01-12
8-K
8-K
2026-01-08
10-Q
10-Q
2025-11-10

SEPN filed its 10-Q on November 10, 2025. The filing includes a section on Risk Factors under Item 1A, although specific financial highlights and detailed risk descriptions were not provided in the available excerpt.

8-K
8-K
2025-11-10
8-K
8-K
2025-09-29

Septerna filed an 8-K on September 29, 2025, likely reporting third-quarter financial results or a material corporate development.

8-K
8-K
2025-09-03
8-K
8-K
2025-08-21
10-Q
10-Q
2025-08-11
8-K
8-K
2025-08-11
8-K
8-K
2025-08-04
8-K
8-K
2025-07-02
Data sourced from SEC EDGAR. AI summaries generated automatically.

Wall Street Analysts

Professional analyst ratings and price targets

Consensus
STRONG_BUY
7 analysts
HC Wainwright & Co.
2026-04-14
reit
Buy Buy
JP Morgan
2026-03-24
Maintains
Overweight Overweight
Truist Securities
2026-03-11
Maintains
Buy Buy
Wells Fargo
2026-03-03
Maintains
Overweight Overweight
HC Wainwright& Co.
2026-03-02
Maintains
Buy Buy
HC Wainwright & Co.
2026-01-20
Maintains
Buy Buy
Jones Trading
2025-12-23
init
Buy
Raymond James
2025-12-19
init
Strong Buy
Truist Securities
2025-12-15
init
Buy
Wells Fargo
2025-11-14
up
Equal-Weight Overweight

Past News Coverage

Recent headlines mentioning SEPN from our newsroom.

Newest → oldest
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